JSB462 / AR / oral PROTAC androgen receptor degrader / OncologyProstate cancerPhase 2under investigation 7assets epcoritamabGEN3013 / EPKINLY/TEPKINLY / CD20xCD3 / Bispecific antibody / OncologyRelapsed or refractory diffuse large B-cell lymphoma (DLBCL)ApprovedMarketedUSEUJapanRelapsed or refractory follicular lymphoma (FL)ApprovedMarketedUSEURelapsed or refractory FL in combination with rituximab and lenalidomide (R2)ApprovedMarketedUS rinatabart sesutecanRina-S / Rina-S / FR (folate receptor alpha) / Antibody-drug conjugate (ADC) / OncologyPlatinum-resistant ovarian cancerPhase 3ActiveGlobalAdvanced endometrial cancerPhase 1/2ActiveGlobal petosemtamabMCLA-158 / EGFRxLGR5 / Bispecific antibody / OncologyFirst-line head and neck squamous cell carcinoma (HNSCC)Phase 3ActiveGlobalSecond/third-line head and neck squamous cell carcinoma (HNSCC)Phase 3ActiveGlobal daratumumabDARZALEX/DARZALEX FASPRO / CD38 / Monoclonal antibody / OncologyMultiple myeloma (multiple lines)ApprovedMarketedGlobal ofatumumabKesimpta/Arzerra / CD20 / Monoclonal antibody / Neurology/OncologyRelapsing multiple sclerosis (Kesimpta)ApprovedMarketedGlobalChronic lymphocytic leukemia (Arzerra)ApprovedMarketedUSEU tisotumab vedotinTivdak / Tissue factor / Antibody-drug conjugate (ADC) / OncologyRecurrent or metastatic cervical cancerApprovedMarketedUSEUJapan HexaBody-CD38GEN3014 / CD38 / HexaBody monoclonal antibody / OncologyMultiple myelomaPhase 1/2ActiveGlobal 7assets AleniglipronGSBR-1290 / GLP-1R / Oral small molecule agonist / Metabolic / ObesityObesity / overweight with weight-related comorbidityPhase 2 (ACCESS / ACCESS II)
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Additional downstream mediators include ErbB ligands such as epiregulin and vasoactive intestinal polypeptide (VIP) (68)
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It is important to emphasise that these potential benefits are largely theoretical or extrapolated from separate studies, rather than proven through robust clinical trials of the combination
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