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Clinical efficacy of sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide-1 receptor agonist combination therapy in type 2 diabetes mellitus: real-world study

They do lots of different things in lots of different tissues

GLP-1R V229A internalised more slowly than WT receptor after exendin-4 stimulation (Figure 6A-C), with only 10% of V229A internalised after 5-minutes stimulation versus 30% for WT

Local injection near injured tendons may provide advantages over systemic administration for these focal injuries

And proper positioning optimizes the mechanics of defecation