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However, most patients notice weight loss within the first two weeks of treatment

Coverage begins April 2026 under a demonstration project

Young adults (aged 1834) were more likely to drop out of treatment sooner, and more than 30% of all patients dropped out after just four weeks, before reaching the targeted dose

The degree to which leptin and insulin stimulate overall GLP-1 secretion is still unclear, but GIP-mediated GLP-1 release has been shown to occur in rodents via acetylcholine release by the enteric nervous system

Here's what actually happens