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Semaglutide showed the strongest association with reduced epilepsy risk among the GLP-1 drugs evaluated in the study

Below are the rates reported across the SURPASS and SURMOUNT trial programs

Crawford BA, Labio ED, Strasser SI, McCaughan GW

Studies have shown that long-term treatment with vitamin D promotes GABA synthesis in crucial brain areas such as the prefrontal cortex, anterior cingulate cortex, and hippocampus (Al-Amin et al., 2019)

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Dose-escalation decisions in both phases are evaluated by a Safety Review Committee (SRC) , which assesses clinical, pharmacokinetic and safety data according to predefined stopping rules established in the study protocol