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For protocol design: Daily dosing is the standard research convention

Around 50% to 98% of vitamin B12 is excreted from the body 48 hours after injection

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Find out why malabsorption is happening Choose the best treatment method (e.g., injections, sublingual tablets) Keep an eye on how the patient is doing and adjust treatment if needed Medication-Induced B12 Deficiency Management Medication can also cause B12 deficiency

This pathway allowed AOD-9604 to be marketed in the United States as a dietary supplement without the efficacy evidence required for a New Drug Application (NDA)