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While this side effect wasnt recognised in initial clinical trials of weight loss drugs, widespread use of them has revealed this correlation

Reuter, S., et al., Oxidative stress, inflammation, and cancer: how are they linked

It is a small molecule that works by inhibiting the activity of an enzyme called nicotinamide N-methyltransferase (NNMT)

Inside the mitochondria, the electron transport is responsible for a series of redox reactions which result in the resynthesis of ATP

however, CV outcomes trials with these agents showed apparently different treatment effects on CV outcomes

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