This means people following a vegan or vegetarian diet will likely have significantly less beta-alanine and carnosine in their system and require supplementation to enhance athletic performance
Vitamin B-12 (Cyanocobalamin): Role: Vitamin B-12 is an essential nutrient that plays a crucial role in many bodily functions, including energy production, DNA synthesis, and nerve cell health
In: Capaccioli S, Nucci C, Quattrone A, et al., editors

You should contact your GP or diabetes care team if: Cold sensitivity is severe, persistent, or progressively worsening You experience cold intolerance accompanied by other symptoms such as extreme fatigue, constipation, dry skin, hair loss, or unexplained weight gain You develop symptoms suggestive of hypothyroidism (underactive thyroid), which can cause cold sensitivity (note that while GLP-1 receptor agonists have been associated with C-cell tumours in rodent studies, there is no established link to hypothyroidism in humans) You notice signs of anaemia, such as pallor, breathlessness, or palpitations, which can cause cold sensitivity Cold hands or feet are accompanied by colour changes (white, blue, or red), pain, or numbness, which may indicate circulatory problems You experience unexplained fever, chills, or rigors, which could suggest infection You have symptoms of hypoglycaemia (low blood sugar) such as shakiness, sweating, or confusion, especially if you also take insulin or sulfonylureas NICE guidance (NG28) recommends regular monitoring of patients on GLP-1 receptor agonists, including assessment of glycaemic control, weight, and tolerability

You dont want to be caught by surprise
Whilst retatrutide has demonstrated a broadly acceptable safety profile in trials to date, there are important considerations that would likely inform prescribing decisions if and when it receives regulatory approval