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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

The model demonstrated that exposure ratios between the subgroups were similar or slightly smaller on day 10 compared with steady state (details not shown), thereby confirming that the primary conclusions regarding exposure ratios across the 10-day trials are applicable at steady state