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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Curieses Andrs C.M., Prez de la Lastra J.M., Andrs Juan C., Plou F.J., Prez-Lebea E
That signal is preclinical only : Dihexa has never entered a human clinical trial, several of the foundational mechanism papers were retracted in 2025 for falsified/fabricated data [4] , and everything below reflects animal reference data and community conventions provided strictly for research and educational reference not medical advice or a recommendation to self-administer
Nasal bioavailability for systemic effects is low, but the nose-to-brain pathway delivers oxytocin directly to central receptors with good efficiency
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It plays a key role in glucose and appetite regulation by: Stimulating insulin release (glucose-dependent) Suppressing glucagon secretion Slowing gastric emptying Increasing satiety and reducing appetite In people with type 2 diabetes, this GLP-1 response is impaired leading to poor glycemic control
