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Conclusions To summarize, more than 19 years after exenatide's approval, newer once-weekly GLP-1 medicines like semaglutide and tirzepatide have shown long-term efficacy and safety for type 2 diabetes and obesity

However, whilst there is no official prohibition against combining these medications, healthcare professionals must carefully consider the indirect metabolic effects that may arise from their concurrent use

10.1038/ki.2012.240 89 KimuraT.TakabatakeY.TakahashiA.KaimoriJ.MatsuiI.NambaT.et al (2011)

Methionine deactivates estrogen, which increase bile cholesterol

Usually, our bodies make all the carnitine we need