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However, its benefit is mainly dependent on adherence, which remains suboptimal in many patients due to discomfort and inconvenience, with adherence rates often falling below 50% in routine clinical practice [22]
The gastric emptying delay is typically dose-dependent and most pronounced during initial therapy
Choose the same day each week for consistency (many prefer Sunday evenings) Allow refrigerated medication to reach room temperature before injecting Clean the injection site with alcohol and let it dry completely Pinch a fold of skin and insert the needle at a 45-90 degree angle Inject slowly over 5-10 seconds Hold the needle in place for 10 seconds after completing the injection Rotate sites in a systematic pattern (left abdomen, right abdomen, left thigh, right thigh) Injection timing preferences vary among users
Risk factors that increased the likelihood of developing NAION included a history of DR, insulin use, male sex, white race, dual eligibility in Medicare and Medicaid, rural residency, sleep apnea and concurrent use of amiodarone and GLP-1 agonists
However, there is a lack of understanding whether this risk is reversible in those living with obesity
Personal trainers can also be key to the GLP-1 lifestyle
