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Second, the study was powered solely based on anticipated changes in GLP-1 levels and was not designed to detect correlations between GLP-1 or GIP and weight regain (WR), nor to evaluate the differential effects of semaglutide across hormonal subgroups

If you are living with diabetes and considering cannabis: Always talk to your doctor before using it

The answer lies in the delivery

The results showed that compared with the model group, the medium (150 mcg/kg) and high (300 mcg/kg) dose groups of semaglutide significantly increased GLP-1R expression, BMD and serum levels of bone formation markers (BALP, OCN)

So it was precarious

GLP-1 drugs are primarily recommended for: Adults with type 2 diabetes who arent seeing results from oral medications and need better blood sugar control People with obesity or with a BMI over 30 (with or without diabetes) seeking medical weight management Doctors may also consider GLP-1 RAs for patients with cardiovascular risk factors, as some of these drugs have shown heart-protective benefits