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Under certain conditions, PI3K/Akt is also activated as it supports neuronal energy regulation, synaptic function, antioxidant defense, and autophagy (Mller et al., 2019

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[DOI] [PubMed] [Google Scholar] 236.Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, et al

However, their popularity has surged beyond traditional endocrinology clinics

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These detrimental effects exacerbate oxidative stress as documented by a compromised antioxidant system due to high lipid peroxidase (LPO)