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However, despite their effectiveness, GLP-1 agonists are not without drawbackshigh cost, gastrointestinal side effects, long-term dependency, and concerns about sustainability once the drug is discontinued

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While the profile of exendin-4-mediated signalling is more similar to that of GLP-1, there are differences in receptor engagement by the two peptides that can be rationalised by the structural and dynamic data

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doi: 10.1006/bbrc.1999.1060

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