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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64

Those in the control group (not receiving the drug) had a 3.5% annual mortality rate

Liraglutide mimics the natural GLP-1 hormone, which slows gastric emptying, reduces appetite, and enhances feelings of fullness