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doi: 10.1016/j.cmet.2013.04.008 43 DelrueCSpeeckaertMM

PDs lactylation pathology is uniquely triggered by substantia nigra dopaminergic neuron mitochondrial CI deficiency, with key targets including mitochondrial protein lactylation and H3K9la-mediated TNF signaling in microglia

After the first 10 batches, a +/- 2 standard deviation range can be calculated and applied using Westgard 2 or local rules to assess the validity of a batch

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The results of these studies are stimulating the development of better bacterial IMPDH inhibitors to overcome infections (Juvale et al