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Stem cell-based and exosome-based therapies further enrich the therapeutic arsenal by introducing biological and regenerative dimensions

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For instance, AMPK inhibits mTORC1 signaling through phosphorylation of TSC2, while simultaneously activating the deacetylase activity of sirtuin 1 (SIRT1), collectively regulating autophagy and energy metabolism

After 2, 4, and 6 days of culture, the cell number in the PDL9 group was significantly lower than that in the PDL3 group (Figure 1C), which indicated that the proliferative ability of senescent chondrocytes was significantly decreased

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