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Initially developed to manage diabetes, GLP-1 agonists like semaglutide and tirzepatide are gaining recognition for their potential in treating a range of other significant health conditions

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doi: 10.1097/GME.0000000000002310 [DOI] [PMC free article] [PubMed] [Google Scholar] 35.Stewart J

They have been shown to reduce inflammation by targeting various cellular mechanisms, such as inhibiting pro-inflammatory enzymes like cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), modulating mitogen-activated protein kinase (MAPK) pathways, and blocking nuclear factor kappa B (NF-B) activation (59)

TABLE 31 Pharmacokinetic and pharmacodynamic parameters for selected drugs in adults

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