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In addition, the applicant submitted 32 supplemental background articles describing topics including general disease processes and disease prevalence

Calcineurin Inhibitors and Anemia Calcineurin inhibitors (CNI) , tacrolimus and cyclosporine, are associated with microangiopathic hemolytic anemia (MHA) [24, 25]

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The balance between ATP consumption and production is controlled allosterically at three sites: the hexokinase, phosphofructokinase-1, and pyruvate kinase reactions (see Fig