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The duration guide addresses this question, while maintaining weight loss after GLP-1 therapy discusses strategies for the post-treatment period

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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome