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Maintain adequate hydration by sipping water throughout the day, use sugar-free xylitol gum to stimulate saliva production, optimize oral hygiene with fluoride toothpaste and alcohol-free mouth rinse, and consider using a bedroom humidifier at night
Monitoring Recommendations Check INR within 2 to 4 weeks of starting or up-titrating any GLP-1 RA in warfarin-treated patients
Clinical trials suggest Zepbound causes gastrointestinal side effects slightly more frequently than Wegovy, likely due to its dual-receptor action, but the differences arent dramatic
Some may offer an initial consultation within the first week, but others may have a longer onboarding process
Some of these effects are in fact analogous to those previously observed by reducing beta cell/islet cholesterol with simvastatin: for example, both manipulations led to a reduction in GLP-1R plasma membrane lateral diffusion under vehicle conditions, as well as acute increases in GLP-1R-induced cAMP and islet insulin secretion responses
