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In preclinical work, Dihexa promoted dendritic spine formation at concentrations reported to be far more potent than BDNF on a molar basis in specific assays [McCoy et al., 2013]

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In the short-term, placebo-controlled trial in adults with schizophrenia, the adverse event of presyncope was reported in 1/167 (0.6%) of patients treated with ABILIFY MAINTENA, while syncope and orthostatic hypotension were each reported in 1/172 (0.6%) of patients treated with placebo

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