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Differences in receptor binding and pharmacodynamics could explain this observation, but further investigation is needed to determine whether the differences stem from drug properties, population characteristics or both. The authors also disclosed their inability to establish causality for the association between semaglutide and ocular AEs, noting that the biological mechanisms remain unclear

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[DOI] [PubMed] [Google Scholar] 75.Merkul E., Muns J.A., Sijbrandi N.J., Houthoff H.J., Nijmeijer B., van Rheenen G., et al

In this review, we discuss the molecular and cellular mechanisms of immunosenescence and summarize the critical role of immunosenescence in the pathogenesis of age-related diseases