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This lipidation promotes albumin binding, extending its plasma half-life to approximately one week, which allows for once-weekly dosing

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The SURMOUNT-1 trial (tirzepatide, similar population) reported average weight loss up to about 20.9 percent at the highest dose over 72 weeks (Jastreboff AM, et al

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The bioavailability of LA is approximately 30% (2038%), primarily due to the first-pass effect in the liver [18]

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