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The review traced the developmental history of GLP-1 research from the identification of the proglucagon gene in 1982 through to the contemporary landscape of GLP-1-based therapeutics across obesity, cardiovascular disease, NAFLD, neurodegeneration, and cancer biology

Cosmetic changes from GLP-1s Since GLP-1 medications can lead to significant weight loss, some people might notice extra or loose skin

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GLP-1 RAs offer new opportunities to manage T2DM, while also adding additional value in reducing the burden of obesity and overweight, as well as preventing cardiovascular disease

It was showed that a GLP-1 analogue with improved half-life in a NEP 24.11 degradation assay had prolonged action in mice, therefore making this assay relevant to evaluate the potential efficacy in vivo of our compounds 40