Nature 596 , 583589 (2023)
Small RNA-big impact: exosomal miRNAs in mitochondrial dysfunction in various diseases
R2 R3 hexanoyl Tyr He pb heptanoyl Tyr He Pb pentanoyl Tyr He pb butanoyl Tyr He pb propanoyl Tyr He pb acetanoyl Tyr He pb benzoyl Tyr He pb hexanoyl Tyr lie tyrosine and isoleucine at R2 and R 3 , respectively a wide range of amino acid and other residues might be used for the mimetics or agonists (Family 1 and Families 2- 5, respectively) in the practice of embodiments of the invention at these other positions including, without limitation, tyrosine, cysteine, methionine, phenylalaine, aspartic acid, glutamic acid, histidine, tryptophan, lysine, leucine, valine, homocysteine, homoserine, and homophenyalanine
If we were to design vaccines under the assumption that producing the gold-standard pan-coronavirus vaccine is achievable, we would aim to induce immunity that recognizes the breadth of diversity across the Coronaviridae family
Traina, Giovanna
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