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This intermediate is then transported to the liver, where hepatic flavin monooxygenases oxidize it to TMAO, subsequently entering the systemic circulation 15,16,17

To further evaluate the robustness of the age-adjusted findings, additional sensitivity analyses were performed using spline-based ANCOVA to account for potential non-linear age effects and by repeating the analyses using only samples within the overlapping age range between MMA patients and healthy controls

**In a supportive measure, at week 68, at least 20% weight loss was seen in 30% of people taking Wegovy versus 2% of people taking placebo

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