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Parallel to the development of the glucagon-based co-agonists, investigations from an independent research group validated the concept, reporting anti-obesity properties for a chemically modified version of the gut hormone oxyntomodulin (OXM) [79]
Those with a personal history of suicidal ideation or severe depression should undergo psychiatric evaluation before starting therapy, as rare mood changes have been reported
There is a faster track called Priority Review (6 months) for drugs that represent a major improvement over what is already available
After that, most researchers find the side effects stabilize at a tolerable level
When considering cost per pound of weight loss (factoring in effectiveness), semaglutide typically provides better value despite similar monthly costs
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