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With heterogeneous evidence of the cardiovascular benefit, mortality, and potential risks of intensive glycemic control reported in several recent clinical trials, achieving good blood glucose control without increasing cardiovascular risk factors such as hypoglycemia and body weight gain is becoming more important [3,4,5,6,7]

10.1126/science.182.4115.929

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J Child Neurol (2010) 25:12325.10.1177/0883073809361165 64 AdamsJBHollowayC

When CYP3A4 activity drops, medication levels in your body can rise unexpectedly, potentially increasing side effects or changing how the drug works