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Recent studies have revealed that dysregulation of mitochondrial dynamicsincluding impaired mitophagy, imbalances in mitochondrial fusion and fission, and defects in mitochondrial biogenesisis closely associated with CRC initiation, progression, and resistance to therapy [46]

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Postmenopausal women may have a predisposition to osteoporosis induced by glucocorticoids

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Uncoupling of NOs results in a switch from nitric oxide to superoxide radical and peroxynitrite and suppressed bioavailability of nitric oxide and vasoconstriction (Santillo et al

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