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Total: 1 x 10mg + 4 x 20mg = 90mg

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Why doubling works as an escalation strategy The dose steps in the retatrutide schedule roughly double at each level: 2mg to 4mg to 8mg, with the final step from 8mg to 12mg being a 50% increase

In the current analysis in people with MASLD, fasting triglycerides were reduced by greater than 40% by retatrutide 8 mg and 12 mg doses after 48 weeks, and these reductions were significantly associated with reduced liver fat

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