So thats the background biology
While the clinical trials demonstrated excellent safety in generally healthy obese adults, individual medical histories may reveal concerns not apparent in trial populations
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Five years after treatment or remission is used as a conservative review window rather than a proven biological cutoff
However, "better" depends on whether your study focuses on fat burning (1MQ) or metabolic adaptation (MOTS-C)
includes warnings that parenteral thiamine may cause anaphylaxis and that the benzyl alcohol preservative is contraindicated in neonates due to risk of serious reactions)