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Hepatocytes were pre-incubated with either GSH (8 mM), Vitamin E (4 mM) or in combination of both GSH (8 mM) and Vitamin E (4 mM) for a period of 10 min prior to the addition of Rotenone (10 M) and ethanol (20 mM) showed complete protection from cellular toxicity

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The practical implications of this difference extend to manufacturing, patent protection, dosing flexibility, and potentially even clinical outcomes

It is essential to understand that this designation reflects absence of FDA-standard evidence , not documented evidence of harm