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By activating both receptor systems, tirzepatide appears to produce greater weight loss than GLP1 agonists alone

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Managing GI side effects and titration strategies Gastrointestinal adverse events affect 40-70% of treated patients [25], primarily consisting of: Nausea (15-50%) Diarrhea (5-25%) Vomiting (5-10%) Slow titration remains fundamental to mitigating these effects

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