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Seek immediate medical attention for severe abdominal pain, signs of ketoacidosis, severe dehydration, or genital/perineal pain with fever

A Concept Mapp Study among Professionals

These symptoms are usually temporary and often improve within the first several weeks

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EX-4 stimulates the expression of anti-inflammatory M2 microglial markers (including IL-10, IL-4, arginase 1, and CD206), but not that of proinflammatory M1 markers, which are linked to neuroprotection and antinociception in neuropathic rats [50]

These recommendations emphasise a stepped-care approach, with psychological interventions forming the cornerstone of treatment