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The full therapeutic dose may not be reached until 16 to 20 weeks after initiation, which delays maximal efficacy but improves tolerability and treatment adherence

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Metaflammation is chronic, low-grade inflammation that operates at the cellular level, disrupting energy production, impairing insulin signaling, and slowing mitochondrial function

Because of these combined effects, portion sizes naturally become smaller and people find they can no longer finish meals they previously considered normal

2024;7(9) doi: 10.1001/jamanetworkopen.2024.35425