doi:10.1038/s41591-024-02970-5 PubMed: This substudy demonstrated that retatrutide reduced liver fat by 81-82% at the 8mg and 12mg doses over 24 weeks, providing evidence of retatrutides multi-system metabolic benefits beyond weight loss
The growth in the historic period can be attributed to rising prevalence of type 2 diabetes, increased awareness of glycemic control therapies, strong clinical efficacy versus traditional antidiabetics, physician preference for incretin-based therapies, favorable reimbursement in developed markets
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However, these drugs have side effects, including gastrointestinal upset and nausea
Current trials also exclude people with diabetes, recent heart problems, and eating disorders, which may indicate future contraindications once approved
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