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NNT was computed as the reciprocal of the absolute risk reduction for each outcome

[4] The prolonged absorption phase distinguishes estradiol cypionate from shorter-acting aqueous estradiol products and reduces peak-trough fluctuations that may contribute to adverse events or symptom breakthrough

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Women of childbearing potential should be advised that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during dose initiation and escalation periods, and should consider using non-oral or additional contraceptive methods