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Proc Natl Acad Sci U S A 87:334347, PMID: 1970635 Messina JP, Lawrence DA (1989) Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase

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Suboptimal ratio of ACE to ACE2 may explain the heterogeneous responses to the viral infection

It features an arginine substitution at position 3 and an extra 13 amino acids at the N-terminus, making it about three times more potent than native IGF-1 with a half-life of 20-30 hours