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Because Firmicutes and Bacteroidetes are the main dominant microbiota at the level of the phyla, their proportion is related to the disease susceptibility, which may reflect the ecosystem of the gastrointestinal tract to infer the disease status of HT [35, 39]
[15] Methionine donates methyl groups for the synthesis of S-adenosyl-methionine, which in turn drives phosphatidylcholine production and very-low-density lipoprotein assembly, facilitating export of triglycerides from hepatocytes and mitigating diet-induced steatosis
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The use of n-3 PUFA is recommended in treatment of hypertriglyceridaemia in patients with very high TG concentration as an adjuvant treatment, and the latest data, especially those concerning highly purified eicosapentaenoic acid (EPA icosapent ethyl), also indicate that this effect, associated with a significant reduction of TG concentration, translates into a significant reduction in cardiovascular events by 25%
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