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References Balfour, J

N Engl J Med 369(2):145154

Orforglipron is a newer oral option, and retatrutide is an investigational triple agonist not yet approved

Yes, side effects typically continue for 1 to 3 weeks after your last dose as medication gradually clears from your system

Semaglutide functions as a GLP-1 receptor agonist, meaning it activates the same receptors as your bodys natural GLP-1

However, the decision-making process in primary care is challenging, given the complexity of T2D due to comorbidities, time constraints, guidance overload and the changing scientific landscape of available treatments [3]