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Many obesity specialists compare the condition to high blood pressure: Medication can help control it, but it doesn't eliminate the underlying biology

The first Phase 3 trial to report results, TRIUMPH-4, was published on 11 December 2025

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10.1016/j.ejphar.2015.04.017 194 WenqianG.AndreasR.KjeldH.SrenG.Per BendixJ

The results indicated that schisandrin B increased the level of Nrf2 and decreased the level of Kelch-like ECH-related protein 1, an endogenous inhibitor of Nrf2

[7] [8] It remains under investigation and is not available as a licensed prescription medicine