Preclinical studies in rodents have identified a potential signal for thyroid C-cell tumours with GLP-1 receptor agonists
In a statement, the Danish company said the move would help to address "access barriers" to the medicines and "make it easier and more affordable for people in the US to get authentic, FDA-approved Wegovy and Ozempic in the way that best fits their lives." There's little doubt that one of the reasons for the move will be to try to keep pace with arch-rival Eli Lilly in the market for incretin-based therapies for obesity and T2D, particularly the strong growth of Lilly's dual GIP/GLP-1 agonist tirzepatide, whose growth rate is outstripping Novo Nordisk's products
Avoid alcohol if you are currently dealing with vomiting, severe nausea, dehydration, intense reflux, poor food intake, or abdominal pain
Symptoms include tiredness, weakness, shortness of breath with mild exertion, and cold hands and feet
Some obesity medicine specialists suggest higher intakes for specific populations, particularly patients who are physically active, older adults at higher risk for sarcopenia, or those losing weight rapidly
Discussion While GLP-1 RAs are powerful anti-obesity medications (AOMs), they do raise some serious concerns most notably, up to 40% of the profound weight loss induced by these agents can be due to loss of lean mass 3,4,5 and prior studies have shown that a significant portion of this lean mass is muscle 33,34,35
