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For years, the agency maintained three distinct categories for substances used in compounding: Category 1: Substances that have been evaluated and determined to be eligible for compounding because they do not present significant safety risks and meet clinical needs

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Mitochondrial dysfunction in innate immune cells Neutrophils and plasmacytoid dendritic cells (pDCs) produce IFN- under the stimulation of nucleic acidprotein immune complexes (70)