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In a Phase 2a trial, GSBR-1290 resulted in a significant weight loss of 6.2% after 12 weeks, outperforming the placebo group

10.1186/s11671-020-03344-7 119 YuanJ.LiuW.ZhuH.ChenY.ZhangX.LiL.et al (2017)

doi:10.1073/pnas.1522014113 16

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The SURMOUNT trials tested specific titration speeds and found that slower escalation significantly reduced gastrointestinal side effects

Danish drugmaker Novo Nordisk said neither drug is "intended to be used as a lifestyle medication." Hiccups over availability Novo Nordisk told FOX Business that all dose strengths of Wegovy are now available to retail pharmacies nationwide but cautioned that "pharmacies may experience normal delays given the time required to order the product from their local distribution center, and geographical variabilities." The drugmaker also said most doses of Ozempic are available for patients with Type 2 diabetes across the U.S