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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

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10.1080/13543776.2020.1720649 181 ParkJ

Poor sleep impairs tissue repair, elevates inflammatory markers, and lowers pain tolerance all of which directly impact foot and ankle conditions