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Event and health state disutilities were sourced from the literature and selected to represent the marginal complication-specific disutility of each complication

Through ongoing professional guidance, the journey from frequent acute episodes to long-term stability becomes achievable, empowering individuals to regain energy, reduce complications, and enhance quality of life

This is fundamentally different from interactions where one drug inhibits enzymes that break down the other

A sensitized high-throughput screen identified a series of small molecule GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nM potency