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These unstable intermediate complexes can undergo further chemical transformations into toxic dopamine-derived species, and such dopamine-quinone derivatives are well-documented to impair mitochondrial function and exert direct neurotoxic effects on SN dopaminergic neurons, contributing to their selective vulnerability in pathological states like PD (126)

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Water Res., 13 : 623-626

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Combined with the study data showing near-complete absence in milk, the evidence suggests tirzepatide has a similarly favorable profile during lactation