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FOXO4 protein is a prominent member of the group of transcription factors classified as exhibiting potential to regulate growth and differentiation

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This series of signal transductions ultimately regulates the expression of microphthalmia-associated transcription factor (MITF), thereby initiating the transcription and production of melanin synthesis-related enzymes, laying the foundation for melanin synthesis

Workers exposed to plants containing parthenolide were thought to be susceptible to contact dermatitis, but current reports state that the drug is mutagenic in vivo and in vitro due to oxidative DNA damage or other possible mechanisms, raising concerns about the genotoxicity of the drug