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(159), Kubo et al

High fructose feeding induces copper deficiency in Sprague-Dawley rats: a novel mechanism for obesity related fatty liver

30:57: A recent, retrospective paper on exceptionally long-lived humans finds they have low levels of IGF-1

Animal proteins are the primary B12 source

Matrix-related gene activity

It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number